Ctrl+S doesnt work
Ctrl+S doesnt work. It works changing it with F10 for instance.
one of my most used shortcuts - works for me and I assume for nearly everyone else.
Without more info what exactly you do it’s hardly possible to help.
At a guess you have mapped something else to the same hotkey using the Shortcut mapper. This used to be invisible (except that one mapping masked the other) but with version 7 keys that are multiply mapped are highlighted.
This would explain why changing the key to F10 makes it work.